Medicinal Chemistry and Pharmacology
- Host School/Campus KRICT School
Introduce
The goal of the Medicinal Chemistry and Pharmacology Major is to cultivate talented individuals with on-site experience who specialize in developing new drugs in creative ways. In this major, students learn theories and core technologies essential to new drug development while conducting research projects on candidate substances for new drugs (to treat cancer, infections, diabetes, etc.) Students are conducting candidate substance discovery research by researching compound molecule designs based on organic chemistry, organic synthesis, optimization through a quantitative-structure activity relationship analysis, and the efficacy screening, mechanisms, pharmacokinetic properties, medicamentous properties and delivery of synthesis compounds.
| 세부 전공명 | 전공내용 |
|---|---|
| Medicinal Chemistry | Medicinal chemistry is an interdisciplinary science from synthetic organic chemistry, pharmacology, and computational chemistry. Medicinal chemistry activity includes design, chemical synthesis, and structure-activity-relationship (SAR) analysis toward bio-active small molecules. As an entry level medicinal chemist, students are trained with strong synthetic organic chemistry and instrumental analysis, problem-solving. |
| Pharmacology | 1. Development of novel drug screening technology and its application to drug discovery 2. Research on anticancer, antiviral, cardioprotective drugs 3. Research on drug discovery platform technologies including pharmacokinetics, DDS, and HTS |
Current status of student majors
| Enrolled Students | 18 | Average age of new students in master course | 24.61 |
|---|---|---|---|
| Students on leave | - | Average age of new students in doctor course | 29.1 |
| Completion Students | 13 | Average age of new students in integrative course | 28.54 |
| Master Graduates | 71 | Average graduation period in master course | 2.08 |
| Doctoral Graduates | 18 | Average graduation period in doctor course | 4.28 |
| International Students | 5 | Average graduation period in inegrative course | 4.97 |
Student Research Performance
| Year | Field of Research | Journal | Research |
|---|---|---|---|
| 2020 | Journal | ACS Synthetic Biology | A Chemical Switch System to Modulate Chimeric Antigen Receptor T |
| 2020 | Journal | Bioorganic & Medicinal Chemistry Letters | Discovery of 4-hydroxy-2-oxo-1,2-dihydroquinolines as potential inhibitors of Streptococcus pneumoniae, including drug-resistant strains |
| 2020 | Journal | Journal of Agricultural and Food Chemistry | Discovery of New Triterpenoid Saponins Isolated from Maesa japonica with Antifungal Activity against Rice Blast Fungus Magnaporthe oryzae |
| 2020 | Journal | ACS Medicinal Chemistry Letters | Discovery of a new sulfonamide hepatitis B capsid assembly modulator |
| 2020 | Journal | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | Identification of TRD-35 as potent and selective DRAK2 inhibitor |
| 2020 | Journal | Scientific Reports | Identification of novel compounds, oleanane- and ursane-type triterpene glycosides, from Trevesia palmata: their biocontrol activity against phytopathogenic fungi |
| 2020 | Journal | Organic Chemistry Frontiers | Photoredox-Catalyzed Halotrifluoromethylations of Alkynes with Triethylammonium Halides: Synthesis of Tetrasubstituted Alkenes Containing CF3 and Halogens |
| 2019 | Journal | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | Discovery of 1,2-Naphthoquinone Derivatives as Potent p53-MDM2 Interaction Inhibitors |
| 2019 | Journal | angewandte chemie international edition | Reductive C2Alkylation of Pyridine and Quinoline NOxides Using Wittig Reagents |
| 2019 | Journal | organic letters | Visible-Light-Mediated Photoredox-Catalyzed Regio- and Stereoselective Chlorosulfonylation of Alkynes |
| 2018 | Journal | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | Allosteric Inhibitor TREA0236 Containing Nonhydrolysable Quinazoline4one for EGFR T790M/C797S Mutants Inhibition |
| 2018 | Journal | JOURNAL OF ORGANIC CHEMISTRY | DBU-Promoted Dynamic Kinetic Resolution in Rh-Catalyzed Asymmetric Transfer Hydrogenation of 5-Alkyl Cyclic Sulfamidate Imines: Stereoselective Synthesis of Functionalized 1,2-Amino Alcohols |
| 2018 | Journal | ORGANIC & BIOMOLECULAR CHEMISTRY | Grignard-mediated rearrangement of trifluoroacetyl from dihydroisoquinoline enamides to afford tertiary trifluoromethylcarbinols |
| 2018 | Journal | JOURNAL OF ORGANIC CHEMISTRY | Synthesis and Anti-inflammatory Evaluation of 2-Aminobenzaldehydes via Ir(III)-Catalysed C-H Amidation of Aldimines with Acyl Azides |
| 2017 | Journal | BIOORGANIC & MEDICINAL CHEMISTRY | Discovery of novel tetrahydroisoquinoline-containing pyrimidines as ALK inhibitors |
| 2017 | Journal | Asian Journal of Organic Chemistry | Palladium-Hydride-Catalyzed Regiodivergent Isomerization of 1-Alkenes |
| 2017 | Journal | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R |
| 2016 | Journal | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening |
| 2016 | Journal | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | Reactivation of Paraoxon-inhibited Acetylcholinesterase by Monoquaternary Pyridinium Oximes with N-Alkylbromide Side Chains |
| 2016 | Journal | ARCHIVES OF PHARMACAL RESEARCH | Trans-fused 5-[(tert-Butoxtycarbonyl)amino]octahydroindenes as a Protease Activated Receptor-1 (PAR1) Antagonist |
| 2015 | Journal | European journal of medicinal chemistry | Discovery and optimization of adamantane carboxylic acid derivatives |
| 2015 | Journal | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | Discovery of substituted 6-pheny-3H-pyridazin-3-one derivatives as novel c-Met kinase inhibitors |
| 2015 | Journal | European Journal of Medicinal Chemistry | Efficient synthesis of 3H,30H-spiro[benzofuran-2,10-isobenzofuran]-3,30-dione as novel skeletons specifically for influenza virus type B inhibition |
| 2015 | Journal | Journal of controlled release | Gold cluster-labeled thermosensitive liposmes enhance triggered drug release in the tumor microenvironment by a photothermal effect |
| 2015 | Journal | Journal of organic chemistry | Stereoselective Synthesis of 4-substituted cyclic sulfamidate-5-phosphonates by using Rh-catalyzed, asymmetric transfer hydrogenation with accompanying dynamic kinetic resolution |
| 2015 | Journal | Antiviral Research | Synthesis and anti-influenza virus activity of 4-oxo- or thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-ones |
| 2015 | Journal | Acta Biomaterialia | Therapeutic efficacy of doxorubicin delivery by a CO2 generating liposomal platform in breast carcinoma |
| 2014 | Journal | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2-Heteroaryl Benzimidazole Derivatives as Melanin Concentrating Hormone Receptor 1 (MCH-R1) Antagonists |
| 2014 | Journal | Bull. Korean Chem. Soc | 4-Aminophthalazin-1(2H)-one Derivatives as Melanin Concentrating Hormone Receptor 1 (MCH-R1) Antagonists |
| 2014 | Journal | Journal of the Korean Chemical Society | CT 조영을 위한 금 코팅 리포솜의 제조 |