캠퍼스 이미지

Medicinal Chemistry and Pharmacology

Host School/Campus
KRICT School
Introduce

The goal of the Medicinal Chemistry and Pharmacology Major is to cultivate talented individuals with on-site experience who specialize in developing new drugs in creative ways. In this major, students learn theories and core technologies essential to new drug development while conducting research projects on candidate substances for new drugs (to treat cancer, infections, diabetes, etc.) Students are conducting candidate substance discovery research by researching compound molecule designs based on organic chemistry, organic synthesis, optimization through a quantitative-structure activity relationship analysis, and the efficacy screening, mechanisms, pharmacokinetic properties, medicamentous properties and delivery of synthesis compounds.

세부전공
세부 전공명, 전공내용으로 구분하여 안내합니다.
세부 전공명 전공내용
Medicinal Chemistry Medicinal chemistry is an interdisciplinary science from synthetic organic chemistry, pharmacology, and computational chemistry. Medicinal chemistry activity includes design, chemical synthesis, and structure-activity-relationship (SAR) analysis toward bio-active small molecules. As an entry level medicinal chemist, students are trained with strong synthetic organic chemistry and instrumental analysis, problem-solving.
Pharmacology 1. Development of novel drug screening technology and its application to drug discovery
2. Research on anticancer, antiviral, cardioprotective drugs
3. Research on drug discovery platform technologies including pharmacokinetics, DDS, and HTS

Current status of student majors

Current status of student majors
Enrolled Students 18 Average age of new students in master course 24.61
Students on leave - Average age of new students in doctor course 29.1
Completion Students 13 Average age of new students in integrative course 28.54
Master Graduates 71 Average graduation period in master course 2.08
Doctoral Graduates 18 Average graduation period in doctor course 4.28
International Students 5 Average graduation period in inegrative course 4.97

Student Research Performance

Search
소속전공 정보
소속전공 제공합니다.
Year Field of Research Journal Research
2020 Journal ACS Synthetic Biology A Chemical Switch System to Modulate Chimeric Antigen Receptor T
2020 Journal Bioorganic & Medicinal Chemistry Letters Discovery of 4-hydroxy-2-oxo-1,2-dihydroquinolines as potential inhibitors of Streptococcus pneumoniae, including drug-resistant strains
2020 Journal Journal of Agricultural and Food Chemistry Discovery of New Triterpenoid Saponins Isolated from Maesa japonica with Antifungal Activity against Rice Blast Fungus Magnaporthe oryzae
2020 Journal ACS Medicinal Chemistry Letters Discovery of a new sulfonamide hepatitis B capsid assembly modulator
2020 Journal BULLETIN OF THE KOREAN CHEMICAL SOCIETY Identification of TRD-35 as potent and selective DRAK2 inhibitor
2020 Journal Scientific Reports Identification of novel compounds, oleanane- and ursane-type triterpene glycosides, from Trevesia palmata: their biocontrol activity against phytopathogenic fungi
2020 Journal Organic Chemistry Frontiers Photoredox-Catalyzed Halotrifluoromethylations of Alkynes with Triethylammonium Halides: Synthesis of Tetrasubstituted Alkenes Containing CF3 and Halogens
2019 Journal BULLETIN OF THE KOREAN CHEMICAL SOCIETY Discovery of 1,2-Naphthoquinone Derivatives as Potent p53-MDM2 Interaction Inhibitors
2019 Journal angewandte chemie international edition Reductive C2­Alkylation of Pyridine and Quinoline N­Oxides Using Wittig Reagents
2019 Journal organic letters Visible-Light-Mediated Photoredox-Catalyzed Regio- and Stereoselective Chlorosulfonylation of Alkynes
2018 Journal BULLETIN OF THE KOREAN CHEMICAL SOCIETY Allosteric Inhibitor TREA­0236 Containing Non­hydrolysable Quinazoline­4­one for EGFR T790M/C797S Mutants Inhibition
2018 Journal JOURNAL OF ORGANIC CHEMISTRY DBU-Promoted Dynamic Kinetic Resolution in Rh-Catalyzed Asymmetric Transfer Hydrogenation of 5-Alkyl Cyclic Sulfamidate Imines: Stereoselective Synthesis of Functionalized 1,2-Amino Alcohols
2018 Journal ORGANIC & BIOMOLECULAR CHEMISTRY Grignard-mediated rearrangement of trifluoroacetyl from dihydroisoquinoline enamides to afford tertiary trifluoromethylcarbinols
2018 Journal JOURNAL OF ORGANIC CHEMISTRY Synthesis and Anti-inflammatory Evaluation of 2-Aminobenzaldehydes via Ir(III)-Catalysed C-H Amidation of Aldimines with Acyl Azides
2017 Journal BIOORGANIC & MEDICINAL CHEMISTRY Discovery of novel tetrahydroisoquinoline-containing pyrimidines as ALK inhibitors
2017 Journal Asian Journal of Organic Chemistry Palladium-Hydride-Catalyzed Regiodivergent Isomerization of 1-Alkenes
2017 Journal EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R
2016 Journal BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening
2016 Journal BULLETIN OF THE KOREAN CHEMICAL SOCIETY Reactivation of Paraoxon-inhibited Acetylcholinesterase by Monoquaternary Pyridinium Oximes with N-Alkylbromide Side Chains
2016 Journal ARCHIVES OF PHARMACAL RESEARCH Trans-fused 5-[(tert-Butoxtycarbonyl)amino]octahydroindenes as a Protease Activated Receptor-1 (PAR1) Antagonist
2015 Journal European journal of medicinal chemistry Discovery and optimization of adamantane carboxylic acid derivatives
2015 Journal BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Discovery of substituted 6-pheny-3H-pyridazin-3-one derivatives as novel c-Met kinase inhibitors
2015 Journal European Journal of Medicinal Chemistry Efficient synthesis of 3H,30H-spiro[benzofuran-2,10-isobenzofuran]-3,30-dione as novel skeletons specifically for influenza virus type B inhibition
2015 Journal Journal of controlled release Gold cluster-labeled thermosensitive liposmes enhance triggered drug release in the tumor microenvironment by a photothermal effect
2015 Journal Journal of organic chemistry Stereoselective Synthesis of 4-substituted cyclic sulfamidate-5-phosphonates by using Rh-catalyzed, asymmetric transfer hydrogenation with accompanying dynamic kinetic resolution
2015 Journal Antiviral Research Synthesis and anti-influenza virus activity of 4-oxo- or thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-ones
2015 Journal Acta Biomaterialia Therapeutic efficacy of doxorubicin delivery by a CO2 generating liposomal platform in breast carcinoma
2014 Journal BULLETIN OF THE KOREAN CHEMICAL SOCIETY 2-Heteroaryl Benzimidazole Derivatives as Melanin Concentrating Hormone Receptor 1 (MCH-R1) Antagonists
2014 Journal Bull. Korean Chem. Soc 4-Aminophthalazin-1(2H)-one Derivatives as Melanin Concentrating Hormone Receptor 1 (MCH-R1) Antagonists
2014 Journal Journal of the Korean Chemical Society CT 조영을 위한 금 코팅 리포솜의 제조