Medicinal Chemistry and Pharmacology
- Host School/Campus KRICT School
Introduce
The goal of the Medicinal Chemistry and Pharmacology Major is to cultivate talented individuals with on-site experience who specialize in developing new drugs in creative ways. In this major, students learn theories and core technologies essential to new drug development while conducting research projects on candidate substances for new drugs (to treat cancer, infections, diabetes, etc.) Students are conducting candidate substance discovery research by researching compound molecule designs based on organic chemistry, organic synthesis, optimization through a quantitative-structure activity relationship analysis, and the efficacy screening, mechanisms, pharmacokinetic properties, medicamentous properties and delivery of synthesis compounds.
| 세부 전공명 | 전공내용 |
|---|---|
| Medicinal Chemistry | Medicinal chemistry is an interdisciplinary science from synthetic organic chemistry, pharmacology, and computational chemistry. Medicinal chemistry activity includes design, chemical synthesis, and structure-activity-relationship (SAR) analysis toward bio-active small molecules. As an entry level medicinal chemist, students are trained with strong synthetic organic chemistry and instrumental analysis, problem-solving. |
| Pharmacology | 1. Development of novel drug screening technology and its application to drug discovery 2. Research on anticancer, antiviral, cardioprotective drugs 3. Research on drug discovery platform technologies including pharmacokinetics, DDS, and HTS |
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Yi Kyu Yang Chief major professor
Medicinal and Organic Chemistry, Discovery of new drug research for cardiovascular diseases
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Detailed Info. Name Yi Kyu Yang Position Professor/Chief major professor Research Medicinal and Organic Chemistry, Discovery of new drug research for cardiovascular diseases Major Medicinal Chemistry and Pharmacology Institute Departments 의약바이오연구본부 정보융합신약연구센터 E-mail Homepage Tel 042-860-7143 Education 1982-02 / Seoul National University / Bachelor's
1984-02 / Korea Advanced Institute of Science and Technology / Master's
1987-02 / Korea Advanced Institute of Science and Technology / Doctor's
Research Results
- Chae Jo Lim, Seong Eun Woo, Su Ik Ko, Byung Ho Lee, Kwang-Seok Oh, Kyu Yang Yi* , Benzo[b]thipphene-2-carboxamide derivatives as potent urotensin-II receptor antagonists, Bioorg. Med. Chem. Lett. 2016, 26(19), 4684-4686.
- Jeong Hyun Lee, Ho Won Seo, Jae Yong Ryu, Chae Jo Lim, Kyu Yang, Kwang-Seok Oh,* Byung Ho Lee,*, KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Imrpoves Cardiac Function in Heart Failure, Biomolecules & Therapeutics 2020, 28(5), 482-489.
- Chae Jo Lim*, Nam Hui Kim, Hye Jin Park, Byung Ho Lee, Kwang-Seok Oh, Kyu Yang Yi*, Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists, Bioorganic & Medicinal Chemistry Letters 2019, 29(4), 577-580.
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Young-Sik Jung Campus professor representative
Antiviral drug discovery
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Detailed Info. Name Young-Sik Jung Position Professor/Campus professor representative Research Antiviral drug discovery Major Medicinal Chemistry and Pharmacology Institute Departments 한국화학연구원 의약바이오연구본부 E-mail Homepage Tel 042-860-7135 Education 1984-02 / Pusan National University / Bachelor's
1986-02 / Korea Advanced Institute of Science and Technology / Master's
1993-10 / University of Maryland / Doctor's
Research Results
- Kim, Jinwoo; Shin, Jin Soo; Ahn, Sunjoo; Han, Soo Bong; Jung, Young-Sik,* “3-Aryl-1,2,4-oxadiazole Derivatives Active Against Human Rhinovirus” ACS Medicinal Chemistry Letters, 2018, 9(7), 667-672.
- Kim, Jinwoo; Jung, Yu Kyoung; Kim, Chonsaeng*; Shin, Jin Soo; Scheers, Els; Lee, Joo-Youn; Han, Soo Bong; Lee, Chong-Kyo; Neyts*, Johan; Ha, Jae-Du; Jung, Young-Sik,* et al, “A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication” Journal of Medicinal Chemistry, 2017, 60(13), 5472-5492.
- Kumar Biswas, Bishyajit; Malpani, Yashwardhan R.; Ha, Neul; Kwon, Do-Hyun; Shin, Jin Soo; Kim, Hae-Soo; Kim, Chonsaeng; Han, Soo Bong; Lee, Chong-Kyo; Jung, Young-Sik,* “Enterovirus inhibitory activity of C-8-tert-butyl substituted 4-aryl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-ones” Bioorganic & Medicinal Chemistry Letters, 2017, 27(15), 3582-3585.
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KOH BYUMSEOK ERIC
Drug screening using organoids/Application of Nanobiomaterials
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Detailed Info. Name KOH BYUMSEOK ERIC Position Associate professor Research Drug screening using organoids/Application of Nanobiomaterials Major Medicinal Chemistry and Pharmacology Institute Departments 신약기반기술연구센터 E-mail Homepage Tel 01021791051 Education 2008-06 / University of Wisconsin-Madison / Bachelor's
2013-12 / Univ Michigan-Ann Arbor / Doctor's
Research Results
- Byumseok Koh/Two-Photon Probe for TNF-α. Assessment of the Transmembrane TNF-α Level in Human Colon Tissue by Two-Photon Microscopy/Analytical Chemistry/2019.10.30
- Byumseok Koh/Comparative Analysis of Urban Road Dust Compositions in Relation to Their Potential Human Health Impacts/ Environmental Pollution/2019.09.03
- Byumseok Koh/Purification of Boron Nitride Nanotubes Enhances Biological Application Properties/International Journal of Molecular Sciences/2020.02.24
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Young-Chan Kwon
Viral pathogenesis, innate immunity and Vaccine development
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Detailed Info. Name Young-Chan Kwon Position Associate professor Research Viral pathogenesis, innate immunity and Vaccine development Major Medicinal Chemistry and Pharmacology Institute Departments 신종바이러스융합연구단 E-mail Homepage Tel 042-860-7028 Education 2005-08 / Korea University / Bachelor's
2007-08 / Korea University / Master's
2013-08 / Korea University / Doctor's
Research Results
- Kwon et al., Hepatitis C virus E2 envelope glycoprotein induces an immunoregulatory phenotype in macrophages. Hepatology 2019 May 24
- Shim and Kwon et al., Zika virus-immune plasmas from symptomatic and asymptomatic individuals enhance Zika pathogenesis in adult and pregnant mice. mBio 2019 July 2
- Kwon et al., Distinct CD55 isoform synthesis and inhibition of Complement-Dependent Cytolysis by Hepatitis C virus. J Immunol. 2016 Aug 15
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Kim Doyoun
Structure Based Drug Discovery for Neurological Disorders
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Detailed Info. Name Kim Doyoun Position Associate professor Research Structure Based Drug Discovery for Neurological Disorders Major Medicinal Chemistry and Pharmacology Institute Departments 의약바이오연구본부/신약기반기술연구센터 E-mail Homepage Tel 042-860-7549 Education 2005-02 / Sungkyunkwan University / Bachelor's
2007-02 / Sungkyunkwan University / Master's
2013-08 / Sungkyunkwan University / Doctor's
Research Results
- 김정아,김도연등 / Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1/Neuroligin-2 Complex / Neuron/2017,94(6):1121 (2017.06)
- 김도연등/ Sequence preference and structural heterogeneity of BZ junctions./ Nucleic Acids Research/2018,46(19):10504 (2018.11.)
- 권영찬/김도연 교신/Therapeutic Strategies against COVID-19 and Structural Characterization of SARS-CoV-2: A Review/Frontiers in Microbiology/2020,11:1723 (2020.07.)
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Pilho Kim
Drug Discovery (anti-tubercular, anti-viral, anti-cancer agents), Organic synthesis (tetrahydroisoquinolines, natural products)
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Detailed Info.
Detailed Info. Name Pilho Kim Position Professor Research Drug Discovery (anti-tubercular, anti-viral, anti-cancer agents), Organic synthesis (tetrahydroisoquinolines, natural products) Major Medicinal Chemistry and Pharmacology Institute Departments 신약연구본부 E-mail Homepage Tel 042-860-7541 Education 1991-02 / Korea University / Bachelor's
1993-02 / Korea University - Sejong Campus / Master's
2002-03 / University of California / Doctor's
Research Results
- Gangadhar Rao Mathi, Chung Hyo Kang, Heung Kyoung Lee, Raghavendra Achary, Ha-Yeon Lee, Joo-Youn Lee, Jae Du Ha, Sunjoo Ahn, Chi Hoon Park, Chong Ock Lee, Jong Yeon Hwang, Chang-Soo Yun, Hee Jung Jung, Sung Yun Cho, Hyoung Rae Kim*, Pilho Kim*; Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R. Eur. J. Med. Chem. January 27, 2017, 126, 536-549.
- Ye Jin Jang, Raghavendra Achary, Hye Won Lee, Hyo Jin Lee, Chong-Kyo Lee, Soo Bong Han, Young-Sik Jung, Nam Sook Kang, Pilho Kim*, Meehyein Kim*; Synthesis and anti-influenza virus activity of 4-oxo- or thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-ones. Antiviral Res. July, 2014, 107, 66-75.
- Jae-Min Hwang, Taegwon Oh, Takushi Kaneko, Anna M. Upton, Scott G. Franzblau, Zhenkun Ma, Sang-Nae Cho, Pilho Kim*; Design, Synthesis, and Structure？Activity Relationship Studies of Tryptanthrins As Antitubercular Agents. J. Nat. Prod. March 22, 2013, 76 (3) 354-367.
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Kim, Hun
Plant Microbiology
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Detailed Info. Name Kim, Hun Position Professor Research Plant Microbiology Major Medicinal Chemistry and Pharmacology Institute Departments 친환경신물질연구센터 E-mail Homepage Tel 042-860-7436 Education 2001-02 / Korea University / Bachelor's
2003-02 / Seoul National University / Master's
2010-05 / Purdue University / Doctor's
Research Results
- Han et al. Transcription factor PdeR is involved in fungal development, metabolic change, and pathogenesis of gray mold Botrytis cinerea. J Agric Food Chem. 2020
- Ngo et al. Discovery of new triterpenoid saponins isolated from Maesa japonica with antifungal activity against rice blast fungus Magnaporthe oryzae. J Agric Food Chem. 2019
- Kim et al. Identification of novel compounds, oleanane- and ursane-type triterpene glycosides, from Trevesia palmata: their biocontrol activity against phytopathogenic fungi. Sci Rep. 2018
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Seong Jun Park
Small molecule-based Drug Discovery, Direct inhibitors of transcription factors, Organic synthesis (organosulfur chemistry)
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Detailed Info. Name Seong Jun Park Position Professor Research Small molecule-based Drug Discovery, Direct inhibitors of transcription factors, Organic synthesis (organosulfur chemistry) Major Medicinal Chemistry and Pharmacology Institute Departments 정보융합신약연구센터 E-mail Homepage Tel 042-860-7175 Education 2004-02 / Hankuk University of Foreign Studies - Global Campus / Bachelor's
2006-02 / Korea University / Master's
2013-07 / Rheinisch-Westfalische Technische Hochschule Aachen / Doctor's
Research Results
- 정경채,임환정,박성준,서호경,안경옥,이상진,이은숙/c-MycMaxDNA 복합체 형성을 억제하는 화합물/10-1879992/2018년07월12일
- 김상미,강온유,임환정,박성준/Selective Synthesis of N-Cyano Sulfiimine by Dearomatizing Stable Thionium Ions/ACS OMEGA/2020년4월22일
- 임환정,이원형,박성준/Synthesis, Physicochemical Properties, and Biological Activities of 4-(S-Methyl-N-(2,2,2-Trifluoroacetyl)Sulfilimidoyl) Anthranilic Diamide/Molecules/2019년9월23일
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Chi Hoon Park
Anti-Cancer Biology
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Detailed Info. Name Chi Hoon Park Position Professor Research Anti-Cancer Biology Major Medicinal Chemistry and Pharmacology Institute Departments 신약기반기술연구센터 E-mail Homepage Tel 042-860-7416 Education 1999-02 / Seoul National University / Bachelor's
2001-02 / Seoul National University / Master's
2005-08 / Seoul National University / Doctor's
Research Results
- Kang CH, Kim EY, Kim HR, Lee CO, Lee HK, Jeong HG, Choi SU, Yun CS, Hwang JY, Lee JY, Son YH, Ahn S, Lee BH, Jung H, Park CH*./Minor modifications to ceritinib enhance anti-tumor activity in EML4-ALK positive cancer./Cancer Lett./2016.Feb
- Park CH*, Cho SY, Ha JD, Jung H, Kim HR, Lee CO, Jang IY, Chae CH, Lee HK, Choi SU./Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells./BMC Cancer/2016. Jan.
- Kim M, Pyo S, Kang CH, Lee CO, Lee HK, Choi SU, Park CH*./Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer./PLoS One/2018. JUNE
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