캠퍼스 이미지

Medicinal Chemistry and Pharmacology

Host School/Campus
KRICT School
Introduce

The goal of the Medicinal Chemistry and Pharmacology Major is to cultivate talented individuals with on-site experience who specialize in developing new drugs in creative ways. In this major, students learn theories and core technologies essential to new drug development while conducting research projects on candidate substances for new drugs (to treat cancer, infections, diabetes, etc.) Students are conducting candidate substance discovery research by researching compound molecule designs based on organic chemistry, organic synthesis, optimization through a quantitative-structure activity relationship analysis, and the efficacy screening, mechanisms, pharmacokinetic properties, medicamentous properties and delivery of synthesis compounds.

세부전공
세부 전공명, 전공내용으로 구분하여 안내합니다.
세부 전공명 전공내용
Medicinal Chemistry Medicinal chemistry is an interdisciplinary science from synthetic organic chemistry, pharmacology, and computational chemistry. Medicinal chemistry activity includes design, chemical synthesis, and structure-activity-relationship (SAR) analysis toward bio-active small molecules. As an entry level medicinal chemist, students are trained with strong synthetic organic chemistry and instrumental analysis, problem-solving.
Pharmacology 1. Development of novel drug screening technology and its application to drug discovery
2. Research on anticancer, antiviral, cardioprotective drugs
3. Research on drug discovery platform technologies including pharmacokinetics, DDS, and HTS
교수소개 이미지
Photo Professor Name Majors View
  • Yi Kyu Yang Chief major professor Medicinal and Organic Chemistry, Discovery of new drug research for cardiovascular diseases 상세보기 버튼

    Detailed Info.

    Detailed Info.
    Name Yi Kyu Yang Position Professor/Chief major professor
    Research Medicinal and Organic Chemistry, Discovery of new drug research for cardiovascular diseases
    Major Medicinal Chemistry and Pharmacology
    Institute Departments 의약바이오연구본부 정보융합신약연구센터
    E-mail Homepage
    Tel 042-860-7143
    Education 1982-02 / Seoul National University / Bachelor's
    1984-02 / Korea Advanced Institute of Science and Technology / Master's
    1987-02 / Korea Advanced Institute of Science and Technology / Doctor's

    Research Results

    -  Chae Jo Lim, Seong Eun Woo, Su Ik Ko, Byung Ho Lee, Kwang-Seok Oh, Kyu Yang Yi* , Benzo[b]thipphene-2-carboxamide derivatives as potent urotensin-II receptor antagonists, Bioorg. Med. Chem. Lett. 2016, 26(19), 4684-4686.
    -  Jeong Hyun Lee, Ho Won Seo, Jae Yong Ryu, Chae Jo Lim, Kyu Yang, Kwang-Seok Oh,* Byung Ho Lee,*, KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Imrpoves Cardiac Function in Heart Failure, Biomolecules & Therapeutics 2020, 28(5), 482-489.
    -  Chae Jo Lim*, Nam Hui Kim, Hye Jin Park, Byung Ho Lee, Kwang-Seok Oh, Kyu Yang Yi*, Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists, Bioorganic & Medicinal Chemistry Letters 2019, 29(4), 577-580.

    Treatise(Recent 5 yesrs)

    Patent(Recent 5 yesrs)

    Book(Recent 5 years)

    Performance of research project

  • Young-Sik Jung Campus professor representative Antiviral drug discovery 상세보기 버튼

    Detailed Info.

    Detailed Info.
    Name Young-Sik Jung Position Professor/Campus professor representative
    Research Antiviral drug discovery
    Major Medicinal Chemistry and Pharmacology
    Institute Departments 한국화학연구원 의약바이오연구본부
    E-mail Homepage
    Tel 042-860-7135
    Education 1984-02 / Pusan National University / Bachelor's
    1986-02 / Korea Advanced Institute of Science and Technology / Master's
    1993-10 / University of Maryland / Doctor's

    Research Results

    -  Kim, Jinwoo; Shin, Jin Soo; Ahn, Sunjoo; Han, Soo Bong; Jung, Young-Sik,* “3-Aryl-1,2,4-oxadiazole Derivatives Active Against Human Rhinovirus” ACS Medicinal Chemistry Letters, 2018, 9(7), 667-672.
    -  Kim, Jinwoo; Jung, Yu Kyoung; Kim, Chonsaeng*; Shin, Jin Soo; Scheers, Els; Lee, Joo-Youn; Han, Soo Bong; Lee, Chong-Kyo; Neyts*, Johan; Ha, Jae-Du; Jung, Young-Sik,* et al, “A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication” Journal of Medicinal Chemistry, 2017, 60(13), 5472-5492.
    -  Kumar Biswas, Bishyajit; Malpani, Yashwardhan R.; Ha, Neul; Kwon, Do-Hyun; Shin, Jin Soo; Kim, Hae-Soo; Kim, Chonsaeng; Han, Soo Bong; Lee, Chong-Kyo; Jung, Young-Sik,* “Enterovirus inhibitory activity of C-8-tert-butyl substituted 4-aryl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-ones” Bioorganic & Medicinal Chemistry Letters, 2017, 27(15), 3582-3585.

    Treatise(Recent 5 yesrs)

    Patent(Recent 5 yesrs)

    Book(Recent 5 years)

    Performance of research project

  • KOH BYUMSEOK ERIC Drug screening using organoids/Application of Nanobiomaterials 상세보기 버튼

    Detailed Info.

    Detailed Info.
    Name KOH BYUMSEOK ERIC Position Associate professor
    Research Drug screening using organoids/Application of Nanobiomaterials
    Major Medicinal Chemistry and Pharmacology
    Institute Departments 신약기반기술연구센터
    E-mail Homepage
    Tel 01021791051
    Education 2008-06 / University of Wisconsin-Madison / Bachelor's
    2013-12 / Univ Michigan-Ann Arbor / Doctor's

    Research Results

    -  Byumseok Koh/Two-Photon Probe for TNF-α. Assessment of the Transmembrane TNF-α Level in Human Colon Tissue by Two-Photon Microscopy/Analytical Chemistry/2019.10.30
    -  Byumseok Koh/Comparative Analysis of Urban Road Dust Compositions in Relation to Their Potential Human Health Impacts/ Environmental Pollution/2019.09.03
    -  Byumseok Koh/Purification of Boron Nitride Nanotubes Enhances Biological Application Properties/International Journal of Molecular Sciences/2020.02.24

    Treatise(Recent 5 yesrs)

    Patent(Recent 5 yesrs)

    Book(Recent 5 years)

    Performance of research project

  • Young-Chan Kwon Viral pathogenesis, innate immunity and Vaccine development 상세보기 버튼

    Detailed Info.

    Detailed Info.
    Name Young-Chan Kwon Position Associate professor
    Research Viral pathogenesis, innate immunity and Vaccine development
    Major Medicinal Chemistry and Pharmacology
    Institute Departments 신종바이러스융합연구단
    E-mail Homepage
    Tel 042-860-7028
    Education 2005-08 / Korea University / Bachelor's
    2007-08 / Korea University / Master's
    2013-08 / Korea University / Doctor's

    Research Results

    -  Kwon et al., Hepatitis C virus E2 envelope glycoprotein induces an immunoregulatory phenotype in macrophages. Hepatology 2019 May 24
    -  Shim and Kwon et al., Zika virus-immune plasmas from symptomatic and asymptomatic individuals enhance Zika pathogenesis in adult and pregnant mice. mBio 2019 July 2
    -  Kwon et al., Distinct CD55 isoform synthesis and inhibition of Complement-Dependent Cytolysis by Hepatitis C virus. J Immunol. 2016 Aug 15

    Treatise(Recent 5 yesrs)

    Patent(Recent 5 yesrs)

    Book(Recent 5 years)

    Performance of research project

  • Kim Doyoun Structure Based Drug Discovery for Neurological Disorders 상세보기 버튼

    Detailed Info.

    Detailed Info.
    Name Kim Doyoun Position Associate professor
    Research Structure Based Drug Discovery for Neurological Disorders
    Major Medicinal Chemistry and Pharmacology
    Institute Departments 의약바이오연구본부/신약기반기술연구센터
    E-mail Homepage
    Tel 042-860-7549
    Education 2005-02 / Sungkyunkwan University / Bachelor's
    2007-02 / Sungkyunkwan University / Master's
    2013-08 / Sungkyunkwan University / Doctor's

    Research Results

    -  김정아,김도연등 / Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1/Neuroligin-2 Complex / Neuron/2017,94(6):1121 (2017.06)
    -  김도연등/ Sequence preference and structural heterogeneity of BZ junctions./ Nucleic Acids Research/2018,46(19):10504 (2018.11.)
    -  권영찬/김도연 교신/Therapeutic Strategies against COVID-19 and Structural Characterization of SARS-CoV-2: A Review/Frontiers in Microbiology/2020,11:1723 (2020.07.)

    Treatise(Recent 5 yesrs)

    Patent(Recent 5 yesrs)

    Book(Recent 5 years)

    Performance of research project

  • Pilho Kim Drug Discovery (anti-tubercular, anti-viral, anti-cancer agents), Organic synthesis (tetrahydroisoquinolines, natural products) 상세보기 버튼

    Detailed Info.

    Detailed Info.
    Name Pilho Kim Position Professor
    Research Drug Discovery (anti-tubercular, anti-viral, anti-cancer agents), Organic synthesis (tetrahydroisoquinolines, natural products)
    Major Medicinal Chemistry and Pharmacology
    Institute Departments 신약연구본부
    E-mail Homepage
    Tel 042-860-7541
    Education 1991-02 / Korea University / Bachelor's
    1993-02 / Korea University - Sejong Campus / Master's
    2002-03 / University of California / Doctor's

    Research Results

    -  Gangadhar Rao Mathi, Chung Hyo Kang, Heung Kyoung Lee, Raghavendra Achary, Ha-Yeon Lee, Joo-Youn Lee, Jae Du Ha, Sunjoo Ahn, Chi Hoon Park, Chong Ock Lee, Jong Yeon Hwang, Chang-Soo Yun, Hee Jung Jung, Sung Yun Cho, Hyoung Rae Kim*, Pilho Kim*; Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R. Eur. J. Med. Chem. January 27, 2017, 126, 536-549.
    -  Ye Jin Jang, Raghavendra Achary, Hye Won Lee, Hyo Jin Lee, Chong-Kyo Lee, Soo Bong Han, Young-Sik Jung, Nam Sook Kang, Pilho Kim*, Meehyein Kim*; Synthesis and anti-influenza virus activity of 4-oxo- or thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-ones. Antiviral Res. July, 2014, 107, 66-75.
    -  Jae-Min Hwang, Taegwon Oh, Takushi Kaneko, Anna M. Upton, Scott G. Franzblau, Zhenkun Ma, Sang-Nae Cho, Pilho Kim*; Design, Synthesis, and Structure?Activity Relationship Studies of Tryptanthrins As Antitubercular Agents. J. Nat. Prod. March 22, 2013, 76 (3) 354-367.

    Treatise(Recent 5 yesrs)

    Patent(Recent 5 yesrs)

    Book(Recent 5 years)

    Performance of research project

  • Kim, Hun Plant Microbiology 상세보기 버튼

    Detailed Info.

    Detailed Info.
    Name Kim, Hun Position Professor
    Research Plant Microbiology
    Major Medicinal Chemistry and Pharmacology
    Institute Departments 친환경신물질연구센터
    E-mail Homepage
    Tel 042-860-7436
    Education 2001-02 / Korea University / Bachelor's
    2003-02 / Seoul National University / Master's
    2010-05 / Purdue University / Doctor's

    Research Results

    -  Han et al. Transcription factor PdeR is involved in fungal development, metabolic change, and pathogenesis of gray mold Botrytis cinerea. J Agric Food Chem. 2020
    -  Ngo et al. Discovery of new triterpenoid saponins isolated from Maesa japonica with antifungal activity against rice blast fungus Magnaporthe oryzae. J Agric Food Chem. 2019
    -  Kim et al. Identification of novel compounds, oleanane- and ursane-type triterpene glycosides, from Trevesia palmata: their biocontrol activity against phytopathogenic fungi. Sci Rep. 2018

    Treatise(Recent 5 yesrs)

    Patent(Recent 5 yesrs)

    Book(Recent 5 years)

    Performance of research project

  • Seong Jun Park Small molecule-based Drug Discovery, Direct inhibitors of transcription factors, Organic synthesis (organosulfur chemistry) 상세보기 버튼

    Detailed Info.

    Detailed Info.
    Name Seong Jun Park Position Professor
    Research Small molecule-based Drug Discovery, Direct inhibitors of transcription factors, Organic synthesis (organosulfur chemistry)
    Major Medicinal Chemistry and Pharmacology
    Institute Departments 정보융합신약연구센터
    E-mail Homepage
    Tel 042-860-7175
    Education 2004-02 / Hankuk University of Foreign Studies - Global Campus / Bachelor's
    2006-02 / Korea University / Master's
    2013-07 / Rheinisch-Westfalische Technische Hochschule Aachen / Doctor's

    Research Results

    -  정경채,임환정,박성준,서호경,안경옥,이상진,이은숙/c-MycMaxDNA 복합체 형성을 억제하는 화합물/10-1879992/2018년07월12일
    -  김상미,강온유,임환정,박성준/Selective Synthesis of N-Cyano Sulfiimine by Dearomatizing Stable Thionium Ions/ACS OMEGA/2020년4월22일
    -  임환정,이원형,박성준/Synthesis, Physicochemical Properties, and Biological Activities of 4-(S-Methyl-N-(2,2,2-Trifluoroacetyl)Sulfilimidoyl) Anthranilic Diamide/Molecules/2019년9월23일

    Treatise(Recent 5 yesrs)

    Patent(Recent 5 yesrs)

    Book(Recent 5 years)

    Performance of research project

  • Chi Hoon Park Anti-Cancer Biology 상세보기 버튼

    Detailed Info.

    Detailed Info.
    Name Chi Hoon Park Position Professor
    Research Anti-Cancer Biology
    Major Medicinal Chemistry and Pharmacology
    Institute Departments 신약기반기술연구센터
    E-mail Homepage
    Tel 042-860-7416
    Education 1999-02 / Seoul National University / Bachelor's
    2001-02 / Seoul National University / Master's
    2005-08 / Seoul National University / Doctor's

    Research Results

    -  Kang CH, Kim EY, Kim HR, Lee CO, Lee HK, Jeong HG, Choi SU, Yun CS, Hwang JY, Lee JY, Son YH, Ahn S, Lee BH, Jung H, Park CH*./Minor modifications to ceritinib enhance anti-tumor activity in EML4-ALK positive cancer./Cancer Lett./2016.Feb
    -  Park CH*, Cho SY, Ha JD, Jung H, Kim HR, Lee CO, Jang IY, Chae CH, Lee HK, Choi SU./Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells./BMC Cancer/2016. Jan.
    -  Kim M, Pyo S, Kang CH, Lee CO, Lee HK, Choi SU, Park CH*./Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer./PLoS One/2018. JUNE

    Treatise(Recent 5 yesrs)

    Patent(Recent 5 yesrs)

    Book(Recent 5 years)

    Performance of research project